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KMID : 0390119960360010125
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Journal of Pusan Medical College
1996 Volume.36 No. 1 p.125 ~ p.134
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Plasma Plasminogen Activator Inhibitor 1 Activity And Serum Lipoprotein(a) Levels in Non-insulin Dependent diabetic Patients
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Abstract
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Background:
@EN Recently, a number of new putative cardiovascular risk factor have been proposed. Among these are factors in the fibrinolytic system and the lipoprotein (a) [LP (a)]. Plasminogen activator inhibitor 1 (PAI-1) is increased in patients with
diabetes
mellitus and may be contribute to there excess risk of cardiovascular disease. LP (a) in diabetes mellitus remains to be investigated. We want to compare the PAI-1 and LP (a) between diabetics and non diabetics and to assess the relationship
between
PAI-1, LP (a), BMI lipid profile, fasting insulin and C-peptide. We also want to evaluate whether LP (a) may be a risk factor in diabetic microangiopathy.
@ES Methods:
@EN In forty-nine diabetics and thirty non diabetics, we measured the level of PAI-1, LP(a) lipid profile. In addition we measured the Hb A1c, fasting insulin, C-peptide and evaluate for microvascular complication in diabetic patients.
@ES Results:
@EN 1) The mean PAI-1 level was higher in diabetics (27.08±7.92ng/ml) compared with non diabetics (22.03±10.68ng/ml (p<0.05).
2) The LP (a) levels showed no significant difference between two groups.
3) A significant correlation between PAI-1 levels and BMI (r=0.34, p<0.05), Triglyceride (r=0.34, p<0.05), fasting C-peptide (r=0.42, p<0.01) in diabetics. but we could not fine a significant association between LP (a) and other variables.
4) The LP (a) was higher in diabetics with polyneuropathy[35(4-56)mg/dl] than those without polyneuropathy [15(3-50)mg/dl], but there was no correlation between LP (a) and diabetic retinopathy or nephropathy.
@ES Conclusion:
@EN Diabetic patients seem to have higher PAI-1 levels and the PAI-1 levels in diabetics were correlated between BMI, triglyceride and fasting C-peptide. These results suggest PAI-1 level may be a component of syndrome X. The LP (a) level in
diabetics
was not significant increased than non diabetics. But, The LP (a) in diabetics with polyneuropathy is higher than diabetics without polyneuropathy. So, there should be need for further evaluation about LP (a) in diabetics.
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KEYWORD
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